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Febrile seizures are common in children aged 3 months to 5 years. A febrile seizure is caused by an abnormal discharge of electrical charges in the neurons of the brain. Knowledge, experience and behavior of parents affect the success of the first treatment of febrile seizures. Mother's knowledge is the main factor that affects the first treatment of febrile seizures, mothers who have good knowledge about seizures can determine good seizure management for their children. The incidence of febrile seizures can occur in 2%-4% in children and most parents do not understand the handling of febrile seizures, so it requires an educational approach to increase parents' knowledge about febrile seizures. Flyers are one of the educational media that are proven to be effective in increasing the knowledge and behavior of parents in dealing with febrile seizures. The purpose of this study was to analyze the effect of flyer education on mother's knowledge in handling febrile seizures using a quasi-experimental method, as many as 38 respondents were appointed with a purposive sampling approach. The results showed that there was no effect of flyer education on mother's knowledge in handling febrile seizures in children, p value 0.285, this is because the level of knowledge of parents before education tends to be high. The conclusion of this study was that there was no effect of flyer education on mother's knowledge in handling children's febrile seizures.