Analgesic Effect of Solid Dispersion of Ibuprofen-Polyethylene Glycol 4000 on Mice Deutschland Denken Yoken (DDY) Strain

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Dwi Larasati
Anjar Windarsih

Abstract

Ibuprofen is a drug that has water solubility problems. The intrinsic dissolution rate of ibuprofen has been shown to increase through the formation of a solid dispersion due to an increase in the solubility of ibuprofen, thereby increasing the effectiveness of the drug. The aim of this study to determine the effect of solid dispersion formation on the analgesic effect of ibuprofen. The test animals used were mice with a total of 40 animals, divided into 5 groups namely, PEG 4000, ibuprofen dosage of 26 mg/kg weight and solid dispersion of ibuprofen-PEG 4000 dosage of 52, 104 and 156 mg / kg weight. Writhing reflect was counted every 5 minutes and observed for 1 hour. Then the percentage of protection was calculated and continued with data analysis using statistical tests. Groups of solid dispersion of ibuprofen-PEG 4000 using a dosage of 52, 104, and 156 mg/kg weight capable of reducing inflammation pain indicated by reduction of writhing reflect (≥50%). The increase of protection capacity is obtained as the increasing of a dosage administration; 71.68, 85.16, and 91.60%, respectively. The conclusion of this research is an analgesic effect of ibuprofen was increased through solid dispersion formation of ibuprofen-PEG 4000.

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