The Study of Analgesic Effect of Ibuprofen-PEG 6000 Solid Dispersion Using Writhing Test Method

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Dwi Larasati
Renny Sulistian

Abstract

Ibuprofen is a drug used as anti-rheumatic, anti-inflammatory and analgesic-antipyretic. Ibuprofen is practically insoluble in water. The dissolution rate of ibuprofen can be increased by preparing a solid dispersion of ibuprofen-PEG 6000 in the melting method. This study aims to find out the dissolution rate increasing would be followed by the increasing of ibuprofen analgesic effect. The analgesic test was conducted by observing 40 mice divided into 5 groups, namely negative control (CMC NA), positive control (ibuprofen dosage of 26 mg/kg body weight), and three groups (solid dispersion of ibuprofen-PEG 6000 dosages of 52, 104, and 156 mg/kg body weight). 5% v / v acetic acid was given intraperitonel to all groups, 5 minutes after administration of the test material. The number of writhes was observed in 5 minutes interval for 60 minutes and followed by calculation the percent of the protection with the Hendershot-Forsaith equation. Data analysis was carried out using nonparametric statistical of Kruskal Wallis and Mann Whitney using a confidence level of 95%. The result shows that the formation of solid dispersion ibuprofen-PEG 6000 using ratio of 1:1 can increase the analgesic effect of ibuprofen. The increase in protection capacity indicates protection percentage increase 82.68%, 91.57% and 94.23% respectively

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