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Severe Acute Respiratory Syndrome Corona virus 2 (SARS-CoV-2) infectious disease is a global threat worldwide, in Indonesia in December 2020 there were 617,820 positive cases, 505,836 recovered, 18,819 died, 63,698 suspects. SARS-CoV-2 infection in severe cases will cause tissue damage and activate and stimulate an immune response. RNA and SARS-CoV-2 proteins, interact and activate immune system receptors in excess including macrophages, granulocytes including the production of pro-inflammatory cytokines, activation of CD4 + T cells and CD8 + T cells with the aim of controlling viral replication, limiting viral spread, inflammation and clearance. But an immune response that is too active / excessive will cause tissue damage and inflammation known as cytokine storms. Furthermore, if proinflammatory cytokines continue to be produced, it will lead to worsening disease course and prognosis and death in patients with SARS-CoV-2 infection.