Physical Test and Antibacterial Activity of Clove Oil Cream (Syzygium aromaticum, (Linn.) Merr) on Staphylococcus aureus ATCC 25923

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Monik Krisnawati


Clove essential oil is a natural ingredient containing scientifically proven Eugenol to have antibacterial activity. The volatile nature of essential oil causes less adherence to the skin, so it needs to be formulated in the form of a cream. This study aims to determine the effect of clove oil (Syzygium aromaticum) concentration on the physical properties of the cream and the antibacterial activity of the clove oil cream on Staphylococcus aureus bacteria. Cream was made in type M/A (oil in water) using vanishing cream base with 3 kinds of concentrations namely 10%, 20%, and 30%. Physical properties (organoleptic, adhesion, dispersion, and protection) and antibacterial activity against Staphylococcus aureus were measured using well diffusion method tested in this study. Inhibition zone observations and measurements were made after 48 hours of incubation. Test results of physical properties and antibacterial activity were analyzed using statistical tests with a 95% confidence level. The results of physical properties test show that Clove oil cream had protective ability until the 5thminute, Clove oil cream adhesion concentration of 30% had the longest time that was 4 minutes, and the greatest spread of all formula was 7.4 cm. In addition, the 30% Clove oil cream had the best antibacterial activity against Staphylococcus aureuscompared to the 10%, 20% Clove oil cream, vanishing cream, and Gentamicin cream 0.1% which is indicated by the formation of the largest inhibition zone that is 6.53 mm in diameterThe addition of Clove oil concentration in the cream preparation has a significant influence on the physical properties of the cream and the antibacterial activity against Staphylococcus aureus bacteria.


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